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Country region · North America

Midwestern United States

Country region · United States · Pop. 69.6M · #16 region by EV

A public taster of the full Midwestern United States ecosystem on Dealroom — request a demo for live deal flow, founder pedigrees, AI-talent maps, and the full cap table for every company below.

🦄 New unicorns by year
13
Annual $1B+ outcomes, unsmoothed
🐎 Cumulative thoroughbreds
84
Company revenue history, 2016-2025
Enterprise value
$661B
Actual EV series, 2015-2025

Largest rounds

Largest funding rounds in Midwestern United States

A live treemap of $100M+ rounds from the Dealroom API. Each cell is one round into Midwestern United States-headquartered companies, grouped by Dealroom sector.

Largest rounds in Midwestern United States - 2026

Every $100M+ VC round into Midwestern United States-headquartered companies in 2026, grouped by Dealroom sector.
- rounds · - raised
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Startup funnel

Midwestern United States's power-law funnel

From the first cheque written to a $10B+ outcome. Each arrow shows what fraction of companies at one stage graduate to the next, tracked by founding cohort.

Pre-Seed
2,526
Seed
1,988
Series A
1,581
Series B
851
Series C
450
Unicorn
95
Decacorn
9

* C→Unicorn and Unicorn→Decacorn rates are derived from current counts (no founding-cohort data); the four mid-funnel rates use Dealroom's cohort tracking.

VC investment

How much venture capital flows into Midwestern United States

VC investment into Midwestern United States-headquartered, VC-backed companies, broken down by round size, company location, sector and funding stage. Live from the Dealroom Next Gen API.

Notable companies

Top private companies in Midwestern United States

Up to 20 names per tier from Dealroom's tracked dataset. Decacorns are valued $10B+, unicorns $1B+, thoroughbreds have crossed $100M in revenue.

Decacorns $10B+ valuation 9
Horizon TherapeuticsClariosOak Street HealthAcrisureCitadel SecuritiesExact SciencesLineageTempusWorldPay
Unicorns $1B+ valuation 95
Kin InsurancePaylocitySummit Carbon SolutionsElectric Last Mile SolutionsNature’s FyndNICLanzaTechExactTargetSlate AutoOur Next EnergyLoadsmartVivid SeatsOutcome HealthKeyfactorLordstown MotorsG2EnfusionSyntellis Performance SolutionsInspire Medical SystemsGoHealth+75 more
Thoroughbreds+ $100M+ revenue 84
AcrisureEquipmentShareExact SciencesEnova InternationalAlightPaylocityRootTempusGreen Thumb IndustriesSotera HealthRush Street InteractiveNeueHealthAngiDuo SecurityInspire Medical SystemsWorkivaOneStreamVivid SeatsProtolabsFetch Rewards

Academia

Midwestern United States's academic flywheel

Companies founded by university alumni or spun out of research, plus the institutions producing the most founders tied to Midwestern United States.

University-linked startup formation
322
University spinouts
12.7K
Total alumni-founded companies
7,459
Of which startups (<$15M raised)
3,792
Breakouts ($15M-100M)
1,461
Scaleups ($100M+)

Location comparison

How Midwestern United States stacks up

Compare Midwestern United States with peers from the same country (United States) — switch between combined EV, 5-year EV growth, and a growth × size view. Expand the table for the full ranking.

$729B
Midwestern United States
$654B
$264B
$263B
$215B

Combined enterprise value of each ecosystem.

Premium analytics

What we don't show on this page (yet)

Sector breakdowns, founder origins, AI-talent leaderboards and live deal flow are gated to logged-in Dealroom users. Book a demo to access the full Midwestern United States dataset — or see a sample on the Dealroom app.

Sector breakdown
Where Midwestern United States's unicorns concentrate
Fintech
AI / Enterprise SW
Health Tech
Biotech
Cybersecurity
Consumer
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Capital autonomy
Midwestern United States's domestic vs foreign capital mix
% domestic VC by stage
Cross-border lead investors
Sovereign-fund participation
Foreign-LP exposure
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Recent momentum
Midwestern United States's VC investment trajectory by stage
2024 vs 2025 by stage
Round-size trends
Stage-conversion deltas
Quarterly velocity
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Founder origins
Where Midwestern United States's startup founders come from
By country of origin
Per capita
Top universities
Top alumni-factory companies
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AI talent
Top employers of AI talent in Midwestern United States
Core AI roles
Frontier AI roles
YoY hiring growth
Senior + lead engineers
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Deal flow
Live deal flow & funding rounds in Midwestern United States
New rounds last 30 days
Stage breakdown
Active investors
Round-size trends
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Get the full Midwestern United States ecosystem on Dealroom

Live company-by-company deal flow, full cap tables, founder pedigrees, hiring signals and revenue trajectories.