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Septerna

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Biotechnology company discovering and advancing novel small molecule medicines targeting G protein-coupled receptors (GPCRs)

San Francisco, United StatesFounded 2022Biotech & Life Sciences
Valuation $1–2.5B Latest valuation · 2026
Revenue $50–100M Latest reported FY
Headcount 100–500 Current team size
Total funding $100–500M Disclosed equity funding

About Septerna

Septerna is a pioneering startup in the biotechnology sector, focusing on the development of G protein-coupled receptors (GPCRs) drug discovery. GPCRs are proteins that play a crucial role in regulating human physiology and are a significant target for pharmaceuticals. However, many potential GPCR targets have been inaccessible to modern drug discovery technologies. Septerna is changing this scenario with its innovative Native Complex™ Platform.

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The Native Complex™ Platform is a groundbreaking technology that reproduces GPCRs with their original structure, function, and dynamics outside of the cellular environment. This technology allows for the first time, the industrial-scale drug discovery, including structure-based drug design and ultra-large-scale screening for the entire GPCR target class. This opens up new opportunities for previously "undruggable" GPCRs to be used as therapeutic targets.

Septerna's business model is centered around the development and commercialization of this platform. The company's primary clients are likely to be pharmaceutical companies seeking to develop new drugs targeting GPCRs. By offering a solution to a previously unmet need in the pharmaceutical industry, Septerna has positioned itself in a niche market with significant potential for growth.

Septerna generates revenue by licensing its technology to pharmaceutical companies for drug discovery and development. The company also stands to earn from the sale of its proprietary GPCR-targeted medicines.

In summary, Septerna is a game-changer in the biotech industry, leveraging its innovative technology to unlock new therapeutic targets and spearhead a new era of GPCR-targeted medicines.

Source: Dealroom company data

At a glance

Founded
2022
Headquarters
San Francisco, United States
Listing
IPO 2024
Sector
Biotech & Life Sciences
Power Law
Unicorn$1–10B valuation tierColt$25–100M revenue

Latest news

Press, funding announcements and product moves mentioning Septerna.

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Investors

24 investors on the cap table

From Dealroom's funding and investor records, grouped by the round each investor first entered.

Series A15 investors entered at this stage

Series B and later9 investors entered at this stage

Team profiled 12 named & role-tagged
Founders Hidden — book a demo/100 quality score
Key operators 9 quality Hidden — book a demo/100
Potential founders Hidden — book a demo likely future founders
Startup mafia Hidden — book a demo alumni-founded startups
Talent movements Hidden — book a demo in · Hidden — book a demo out past 12 months

Source: Dealroom Talent Intelligence.

Global footprint

Workforce and web traffic by country
Workforce by country
2 countries with
team presence
🇺🇸 United States99.1%
🇪🇸 Spain0.9%
2 countries shown
Web traffic by country
20K monthly visits
across markets
🇨🇳 China64%
🇺🇸 United States26.5%
🇮🇳 India8%
🇵🇭 Philippines2.5%
🇯🇵 Japan1.5%
Top 5 markets shown

Patents

Estimated portfolio value
$131k

16 active patent families included in this estimate.

A patent family groups patent filings for the same invention. Source: Dealroom · PatSnap.

Explore the patent portfolioPatent records, technology areas and peer comparisonsBook a demo

Market sentiment

Posts on X, past 7 days

An AI-synthesised read of the highest-engagement posts about Septerna on X, ranked by likes and reposts, corporate channels excluded.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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