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Pretzel
Developing groundbreaking therapies based on a deep mechanistic understanding of mitochondrial biology
About Pretzel
Pretzel Therapeutics is a pioneering biotech startup focused on addressing mitochondrial dysfunction through genetic research. Mitochondria are the powerhouses of cells, and when they malfunction, it can lead to a variety of serious diseases. Pretzel Therapeutics aims to tackle the genetic causes of these dysfunctions, potentially offering new treatments for diseases that currently have limited or no effective options.
The company operates in the biopharmaceutical sector, specifically targeting mitochondrial diseases. These are often rare and complex conditions that affect energy production in cells, leading to severe health issues. Pretzel Therapeutics serves a niche market of patients suffering from these mitochondrial disorders, as well as the broader medical community that treats these conditions.
Pretzel Therapeutics' business model revolves around drug discovery and development. The company leverages cutting-edge genetic research to identify potential therapeutic targets within the mitochondria. By developing drugs that can correct or mitigate these genetic issues, Pretzel aims to bring new treatments to market. Revenue is generated primarily through the development and eventual sale of these drugs, as well as potential partnerships and licensing agreements with larger pharmaceutical companies.
The leadership team at Pretzel Therapeutics is composed of renowned experts in mitochondrial biology and drug development. Co-founders like Dr. Larsson and Dr. Gustafsson bring decades of experience and a wealth of academic and clinical knowledge to the table. This strong foundation in science and medicine positions Pretzel Therapeutics as a leader in the emerging field of mitochondrial therapeutics.
In summary, Pretzel Therapeutics is a biotech company dedicated to developing treatments for mitochondrial diseases by targeting their genetic roots. The company operates in the specialized biopharmaceutical market, focusing on drug discovery and development to generate revenue.
Source: Dealroom company dataAt a glance
- Status
- Operational
- Founded
- 2019
- Headquarters
- Waltham, United States
- Employees
- 49
- Open positions
- 1
- Dealroom signal
- 79.0/100
- Industry
- Health
- Sub-industry
- BioTechnology
- Sector
- Biotech & Life Sciences, Biotechnology, Spinout, Disease, DT and LS, UKSU, UKSU2010, science-based
- Business model
- Manufacturing
- Client focus
- b2b
- Investment activity
- 1 company, latest Jan 2026
- Capital deployed
- —
- Preferred round
- ACQUISITION
Knowledge graph
More headlines
Funding history
Company financing events and reported valuations.
| Deal type | Date | Amount | Valuation | Investors | Source |
|---|---|---|---|---|---|
| EARLY VCOther financing | Jul 2025 | $0 | — | The Mito Fund | ↗ |
| SERIES AOther financing | Sep 2022 | $73M | $290M | HealthCap · Karolinska Institute · Eir Ventures · Angelini | ↗ |
Growth signals
Latest recorded traffic for Pretzel is 1.7K monthly website visits, down 50% over the last three months. Pretzel's team grew 6.5% over the past year.
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Investments and acquisitions
Recent portfolio relationships for companies that also act as investors or acquirers.
Investors
From Dealroom's funding and investor records, grouped by the round each investor first entered.
Series A11 investors entered at this stage
ARCH Venture Partners
Mubadala Capital
HealthCap
Karolinska Institute
Eir Ventures- ANAngelini
GU Ventures AB
Invus
Cambridge Innovation Capital
Cambridge Enterprise- TFThe Mito Fund
Other known investors2 additional known investors
University of Cambridge
University of Gothenburg
Source: Dealroom Talent Intelligence.
Global footprint
team presence
Market sentiment
An AI-synthesised read of the highest-engagement posts about Pretzel on X, ranked by likes and reposts, corporate channels excluded.
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Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour
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