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Investor profile

ARCH Venture Partners

Venture Capital · Founded 1986 · Chicago, United States

Early-stage venture capital for life sciences discoveries

251 portfolio companies Venture Capital · $44B invested · 481 investments · Investor rank #67 · Last investment 7/2026
Portfolio companies 251 ↑ 37% 5y
Decacorns 18 ↑ 25% 5y
Thoroughbreds 24
01 · Biggest holdings

ARCH Venture Partners’ biggest current holdings.

The most valuable companies ARCH Venture Partners still holds — unicorns and thoroughbreds it has backed, ordered by Dealroom’s latest valuation. Companies that have been acquired or gone public are in Exits instead. Where a cap table names ARCH Venture Partners directly, the stake and its estimated value are shown too.

#CompanyEst. stakeValuationEst. value
  1. 1 PrometheusDecacorn · Robotics · USA $41.0B
  2. 2 Altos LabsUnicorn · Health · USA $6.3B
  3. 3 AledadeUnicorn · Health · USA 7.5% $3.5B $262M
  4. 4 Xaira TherapeuticsUnicorn · Health · USA $2.7B
  5. 5 ResilienceUnicorn · Health · USA $2.5B
  6. 6 Treeline BiosciencesUnicorn · Health · USA $2.1B
  7. 7 Areteia TherapeuticsUnicorn · Health · USA $1.8B
  8. 8 InsitroUnicorn · Health · USA $1.6B
  9. 9 OratomicUnicorn · Semiconductors · USA $1.5B
  10. 10 SonderMind Wellness CentersUnicorn · Health · USA $1.1B

Estimated value = ARCH Venture Partners’ disclosed ownership % × Dealroom’s latest company valuation; direct named stakes only, exited positions excluded. Figures are indicative, not reported marks. See the underlying cap tables on Dealroom →

02 · Exits

ARCH Venture Partners’ biggest exits.

Portfolio companies that IPO’d or were acquired at $1B+, with the valuation recorded at exit and — for those still public — their value today. Exit events come from each company’s funding-round history; entry stage from ARCH Venture Partners’ transaction record.

AbbVie
IPO · 2013
Now $499BHealth
Thermo Fisher Scientific
IPO · 2014
Entered Series B+Now $258BHealth
EMC
IPO · 1986
Now $67BSecurity
Allergan
IPO · 2013
Now $64BHealth
$1.4B IPO · 2020
Now $41BHealth
$96M IPO · 2000
Entered Series ANow $30BHealth
$114M IPO · 2004
Entered Series B+Now $27BHealth
Liberty Media
IPO · 2016
Now $18BMedia
Hologic
IPO · 1990
Now $17BHealth
MedImmune
$16B acquisition · 2007
Health
Array BioPharma
$56M IPO · 2000
Now $11BHealth
IPO · 2019
Entered Series ANow $11BHealth
03 · Portfolio analysis

Where ARCH Venture Partners’ portfolio is concentrated.

Distribution of portfolio companies by headquarters country, sector, entry stage and current growth stage. Across all 251 portfolio companies. "Stage entered" is the first priced round the investor joined, derived from the investor’s transaction history.

By countryCount
  1. USA327
  2. China12
  3. UK5
  4. Ireland3
  5. Cuba2
  6. Germany2
  7. Israel2
  8. Singapore2
  9. Sweden2
  10. Canada1
  11. Denmark1
  12. Iceland1
By sectorCount
  1. Health268
  2. Semiconductors20
  3. Enterprise Software17
  4. Energy12
  5. Media10
  6. Food7
  7. Education3
  8. Fashion3
  9. Fintech3
  10. Home Living3
  11. Robotics3
  12. Security3
By stage enteredCount
  1. Series A149
  2. Series B+75
  3. Seed23
By growth stageCount
  1. Late Growth147
  2. Breakout Stage107
  3. Early Growth90
  4. Mature21
04 · Portfolio market map

Inside ARCH Venture Partners’ portfolio.

The 60 highest-funded portfolio companies, of 251 tracked.

Prometheus
Robotics · Decacorn
$41B
Intel Corporation
Semiconductors · Centicorn
$534B
Pfizer
Health · Centicorn
$204B
Altos Labs
Health · Unicorn
$6.3B
Resilience
Health · Unicorn
$2.5B
EQRx
Health
GRAIL
Health · Unicorn
$8.0B
Treeline Biosciences
Health · Unicorn
$2.1B
Xaira Therapeutics
Health · Unicorn
$2.7B
Parabilis Medicines
Health · Unicorn
$4.8B
Sana Biotechnology
Health
$954M
Generate Biomedicines
Health · Unicorn
$2.0B
Aledade
Health · Unicorn
$3.5B
Gossamer Bio
Health
$191M
Vir Biotechnology
Health · Unicorn
$1.1B
Mirador Therapeutics
Health · Unicorn
$2.0B
Maze Therapeutics
Health
$140M
Insitro
Health · Unicorn
$1.6B
ArsenalBio
Health · Unicorn
$1.3B
Neumora Therapeutics
Health
$206M
Kardigan
Health · Unicorn
$1.6B
Lyell Immunopharma
Health
$194M
Metsera
Health · Unicorn
$4.9B
LifeMine Therapeutics
Health
$752M
EGenesis
Health
$764M
Genuity Science
Health
$100M
Ollin Biosciences
Health · Unicorn
$1.3B
Areteia Therapeutics
Health · Unicorn
$1.8B
Brii Biosciences
Health
$415M
CStone Pharmaceuticals
Health
$932M
Sapphire Energy
Energy
Vividion Therapeutics
Health · Unicorn
$1.5B
Verve Therapeutics
Health
$566M
Merck & Co.
Health · Centicorn
$361B
Be Bio
Health
$650M
Aspen Neuroscience
Health
$738M
Denali Therapeutics
Health · Unicorn
$1.5B
Erasca
Health · Unicorn
$6.2B
Ikaria
Health · Unicorn
$2.3B
Prime Medicine
Health
$615M
Sonoma Biotherapeutics
Health · Unicorn
$1.1B
Synchron
Health
$900M
Seaport Therapeutics
Health
$989M
Juno Therapeutics
Health · Unicorn
$9.0B
Tome Biosciences
Health
$512M
Arbor Biotechnologies
Health · Unicorn
$1.1B
Sironax
Health
$800M
Oratomic
Semiconductors · Unicorn
$1.5B
Dewpoint Therapeutics
Health
$600M
Paradigm
Health · Unicorn
$1.0B
Orbital Therapeutics
Health · Unicorn
$1.5B
Chroma Medicine
Health
$540M
CREATE Medicines
Health
$488M
Syros Pharmaceuticals
Health
$1.9M
AgBiome
Food
$464M
Boundless Bio
Health
Rapport Therapeutics
Health · Unicorn
$1.8B
AIRNA
Health
$620M
Rubius Therapeutics
Health
Twist Bioscience
Health · Unicorn
$7.2B
05 · Portfolio founders

Where ARCH Venture Partners’ portfolio founders come from.

178 founders across the 100 highest-funded portfolio companies — by current location, university attended, and the companies they worked at before founding. Sourced from the founder records the API links to each portfolio company.

LocationCount
  1. United States164
  2. United Kingdom3
  3. China2
  4. Australia1
  5. France1
  6. India1
  7. Portugal1
UniversityCount
  1. Massachusetts Institute of Technology18
  2. Harvard University15
  3. Stanford University8
  4. Harvard Medical School7
  5. Harvard Business School5
  6. University of California, Berkeley5
  7. Yale University4
  8. Columbia University3
  9. Duke University3
  10. Northwestern University3
Previous companyCount
  1. Genentech5
  2. Massachusetts Institute of Technology5
  3. Merck & Co.5
  4. Stanford University5
  5. Biogen4
  6. Broad Institute4
  7. Harvard Medical School4
  8. Massachusetts General Hospital4
  9. MyoKardia4
  10. Novartis4
07 · Key people

Key people at ARCH Venture Partners.

Source: Dealroom next-gen API — investor team endpoint.