Ollin Biosciences

Ollin was co-founded by Jason Ehrlich, MD, PhD, who also serves as the CEO. Ehrlich has a background in ophthalmology and previously contributed to the development of the successful eye disease medication Vabysmo during his time at Roche's Genentech. His experience at Kodiak Sciences, where he was chief medical officer, inspired him to create a company focused on portfolio development and clinical execution in ophthalmology. The company's business model is asset-centric, focusing on acquiring and developing a pipeline of clinical and late-stage preclinical programs. This strategy involves in-licensing promising assets from other companies rather than focusing on in-house research.

The company's lead product is OLN324, a bispecific antibody that targets VEGF and Ang2, proteins involved in wet age-related macular degeneration (wAMD) and diabetic macular edema (DME). This drug, licensed from the Chinese company Innovent Biologics, is currently in a Phase 1b clinical trial directly comparing it to Roche's Vabysmo. Ollin's second key program is OLN102, a first-in-class bispecific antibody for treating thyroid eye disease (TED) and the underlying Graves' disease. Licensed from VelaVigo, OLN102 targets both TSHR and IGF-1R receptors and is expected to enter clinical trials in 2026. By inhibiting both pathways, the company aims to offer improved safety and efficacy over existing treatments.