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Investor profile

Two Sigma Ventures

Venture Capital · Founded 2012 · New York City, United States

Two Sigma Ventures invests in companies run by highly driven people with potentially world-changing ideas

114 portfolio companies Venture Capital · $8.7B invested · 214 investments · Investor rank #322 · Last investment 4/2026
Portfolio companies 114 ↑ 36% 5y
Decacorns 3 ↑ 100% 5y
Thoroughbreds 9 ↑ 17% 5y
01 · Biggest holdings

Two Sigma Ventures’ biggest current holdings.

The most valuable companies Two Sigma Ventures still holds — unicorns and thoroughbreds it has backed, ordered by Dealroom’s latest valuation. Companies that have been acquired or gone public are in Exits instead. Where a cap table names Two Sigma Ventures directly, the stake and its estimated value are shown too.

#CompanyEst. stakeValuationEst. value
  1. 1 xAICenticorn · Enterprise Software · USA $250B
  2. 2 EtchedDecacorn · Semiconductors · USA $10.3B
  3. 3 WhoopDecacorn · Health · USA 4% $10.1B $404M
  4. 4 SocureUnicorn · Security · USA 7.5% $4.5B $338M
  5. 5 RemoteUnicorn · Fintech · USA 10% $3.0B $300M
  6. 6 Xaira TherapeuticsUnicorn · Health · USA $2.7B
  7. 7 Bedrock RoboticsUnicorn · Robotics · USA $1.8B
  8. 8 InsitroUnicorn · Health · USA $1.6B
  9. 9 You.comUnicorn · Enterprise Software · USA $1.5B
  10. 10 KallyopeUnicorn · Health · USA $1.2B
  11. 11 Enveda BiosciencesUnicorn · Health · USA $1.0B
  12. 12 RapidSOSUnicorn · Health · USA 6% $1.0B $60M

Estimated value = Two Sigma Ventures’ disclosed ownership % × Dealroom’s latest company valuation; direct named stakes only, exited positions excluded. Figures are indicative, not reported marks. Two Sigma Ventures also appears inside investor groups in Enveda Biosciences, You.com, where a standalone stake isn’t disclosed. See the underlying cap tables on Dealroom →

02 · Exits

Two Sigma Ventures’ biggest exits.

Portfolio companies that IPO’d or were acquired at $1B+, with the valuation recorded at exit and — for those still public — their value today. Exit events come from each company’s funding-round history; entry stage from Two Sigma Ventures’ transaction record.

$11B IPO · 2021
Entered Series B+Now $5.3BSecurity
$5.4B IPO · 2014
Now $1.3BFintech
PowerSchool
$3.6B IPO · 2021
Now $4.1BEducation
$3.5B IPO · 2021
Entered Series ANow $226MHealth
$2.7B IPO · 2021
Entered Series B+Now $1.3BHealth
03 · Portfolio analysis

Where Two Sigma Ventures’ portfolio is concentrated.

Distribution of portfolio companies by headquarters country, sector, entry stage and current growth stage. Across all 114 portfolio companies. "Stage entered" is the first priced round the investor joined, derived from the investor’s transaction history.

By countryCount
  1. USA124
  2. Israel2
  3. Australia1
  4. Canada1
  5. Hungary1
  6. Ireland1
  7. Mexico1
  8. Puerto Rico1
  9. Saint Vincent and the Grenadines1
  10. Singapore1
  11. Sweden1
  12. Switzerland1
By sectorCount
  1. Enterprise Software37
  2. Fintech24
  3. Health24
  4. Security17
  5. Media8
  6. Robotics8
  7. Home Living6
  8. Marketing6
  9. Real Estate6
  10. Transportation5
  11. Education4
  12. Food4
By stage enteredCount
  1. Series A45
  2. Seed43
  3. Series B+25
By growth stageCount
  1. Breakout Stage55
  2. Late Growth43
  3. Early Growth41
04 · Portfolio market map

Inside Two Sigma Ventures’ portfolio.

The 60 highest-funded portfolio companies, of 114 tracked.

xAI
Enterprise Software · Centicorn
$250B
Wealthsimple
Fintech · Unicorn
$7.3B
Xaira Therapeutics
Health · Unicorn
$2.7B
Whoop
Health · Decacorn
$10B
Etched
Semiconductors · Decacorn
$10B
Zymergen
Health
$226M
Socure
Security · Unicorn
$4.5B
Insitro
Health · Unicorn
$1.6B
Carbon Health
Health
Recursion Pharma
Health · Unicorn
$1.3B
Enveda Biosciences
Health · Unicorn
$1.0B
RapidSOS
Health · Unicorn
$1.0B
Remote
Fintech · Unicorn
$3.0B
Kallyope
Health · Unicorn
$1.2B
GitLab
Security · Unicorn
$5.3B
Odeko
Food
$384M
Bedrock Robotics
Robotics · Unicorn
$1.8B
LendingClub
Fintech · Unicorn
$1.3B
SecurityScorecard Inc.
Security
$950M
D2iQ
Hosting
$500M
Mirantis
Enterprise Software
$625M
You.com
Enterprise Software · Unicorn
$1.5B
Anki
Robotics
$100M
Terray Therapeutics
Health
$480M
Juicero
Food
$112M
Timescale
Enterprise Software · Unicorn
$1.0B
Hexagon Bio
Health
$269M
3D Robotics
Real Estate
$212M
Enigma
Enterprise Software
$380M
Rethink Robotics
Robotics
$72M
Crux Informatics
Security
$275M
Exai Bio
Health
$286M
Tive
Transportation
$500M
Pryon
Security
$400M
Verge Genomics
Health
$392M
Osmo
Wellness Beauty
$280M
Freeform
Enterprise Software
$268M
NS1
Hosting
$160M
Gameto
Health
$176M
Xilis
Health
$76M
Cajal Neuroscience
Health
$384M
Flatfile
Transportation
$200M
Steadily
Fintech
$355M
Cerby
Security
$73M
Canary
Security
$120M
Radar.io
Transportation
$220M
Replicated
Enterprise Software
$200M
Bark Technologies
Security
$120M
Anomalo
Security
$165M
Kasisto
Fintech
$62M
Comet
Enterprise Software
$200M
Jibo
Robotics
$52M
Artemis
Security
$200M
Castor
Health
$180M
InsightSquared
Marketing
$43M
Pro.com
Real Estate
$132M
littleBits Electronics
Kids
$169M
Lytics
Marketing
$140M
Rally
Fintech
$228M
NetBox Labs
Enterprise Software
$140M
05 · Portfolio founders

Where Two Sigma Ventures’ portfolio founders come from.

181 founders across the 100 highest-funded portfolio companies — by current location, university attended, and the companies they worked at before founding. Sourced from the founder records the API links to each portfolio company.

LocationCount
  1. United States153
  2. Netherlands4
  3. Canada3
  4. Germany2
  5. Israel2
  6. Mexico2
  7. Peru2
  8. Spain2
  9. Argentina1
  10. Cuba1
UniversityCount
  1. Stanford University17
  2. Harvard University14
  3. Harvard Business School8
  4. University of California, Berkeley8
  5. Columbia University6
  6. Massachusetts Institute of Technology6
  7. Cornell University5
  8. Princeton University4
  9. University of California, Los Angeles4
  10. Carnegie Mellon University3
Previous companyCount
  1. Microsoft11
  2. McKinsey & Company8
  3. Stanford University8
  4. Alphabet | Google7
  5. IBM6
  6. Intel Corporation5
  7. Massachusetts Institute of Technology4
  8. Amazon3
  9. Bloomberg3
  10. Carnegie Mellon University3
07 · Key people

Key people at Two Sigma Ventures.

Source: Dealroom next-gen API — investor team endpoint.