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Investor profile

Flagship Pioneering

Venture Capital · Founded 2000 · Cambridge, United States

Pioneering scientists and professionals who build companies that transform human health and sustainability

123 portfolio companies Venture Capital · $11B invested · 253 investments · Investor rank #234 · Last investment 4/2026
Portfolio companies 123 ↑ 17% 5y
Decacorns 2
Thoroughbreds 12 ↑ 9% 5y
Estimated holdings

Flagship Pioneering’s biggest current holdings.

An estimate of Flagship Pioneering’s largest live positions — disclosed shareholding × Dealroom’s latest valuation — across 4 companies where Flagship Pioneering is a named shareholder, worth about $2.7B in estimated equity value.

#CompanyEst. stakeValuationEst. value
  1. 1 IndigoFood · Unicorn 32% $3.5B $1.1B
  2. 2 InariFood · Unicorn 33% $2.2B $716M
  3. 3 Lila SciencesChemicals · Unicorn 42% $1.3B $546M
  4. 4 Valo HealthHealth · Unicorn 32% $950M $304M

Estimated value = Flagship Pioneering’s disclosed ownership % × Dealroom’s latest company valuation; direct named stakes only, exited positions excluded. Figures are indicative, not reported marks. See the underlying cap tables on Dealroom →

Exits

Flagship Pioneering’s biggest exits.

Portfolio companies that IPO’d or were acquired at $1B+, with the valuation recorded at exit and — for those still public — their value today. Exit events come from each company’s funding-round history; entry stage from Flagship Pioneering’s transaction record.

$7.5B IPO · 2018
Entered Series ANow $19BHealth
$385M IPO · 2013
Entered Series B+Now $12BHealth
$324M IPO · 2019
Entered Series B+Now $3.0BHealth
$2.0B IPO · 2026
Entered Series B+Now $2.0BHealth
$1.8B IPO · 2018
Entered Series ANow Health
$250M IPO · 2017
Entered Series ANow $1.5BHealth
IPO · 2013
Entered SeedNow $1.4BHealth
Portfolio analysis

Where Flagship Pioneering’s portfolio is concentrated.

Distribution of portfolio companies by headquarters country, sector, entry stage and current growth stage. Across all 123 portfolio companies. "Stage entered" is the first priced round the investor joined, derived from the investor’s transaction history.

By countryCount
  1. USA120
  2. Belgium1
  3. Canada1
  4. UK1
By sectorCount
  1. Health81
  2. Food9
  3. Energy7
  4. Marketing5
  5. Enterprise Software4
  6. Media4
  7. Chemicals2
  8. Education2
  9. Fintech2
  10. Security2
  11. Telecom2
  12. Transportation2
By stage enteredCount
  1. Series A77
  2. Series B+33
  3. Seed10
By growth stageCount
  1. Breakout Stage57
  2. Late Growth47
  3. Early Growth18
  4. Mature1
Portfolio market map

Inside Flagship Pioneering’s portfolio.

The 60 highest-funded portfolio companies, of 123 tracked.

Moderna Therapeutics
Health · Decacorn
$19B
Johnson & Johnson Innovative Medicine
Health
Indigo
Food · Unicorn
$3.5B
Sana Biotechnology
Health
$877M
Inari
Food · Unicorn
$2.2B
Generate Biomedicines
Health · Unicorn
$2.0B
Tessera Therapeutics
Health · Unicorn
$1.5B
Lila Sciences
Health · Unicorn
$1.3B
Laronde
Health · Unicorn
$1.8B
Valo Health
Health
$950M
Denali Therapeutics
Health · Unicorn
$1.5B
Editas Medicine
Health
$306M
Cellarity
Health
$484M
Harbinger Health
Health
$700M
Senda Biosciences
Health
$492M
Ring Therapeutics
Health
$585M
Syros Pharmaceuticals
Health
$1.9M
Rubius Therapeutics
Health
Omega Therapeutics
Health
Joule Unlimited
Energy
$200M
Evelo Biosciences (Formerly Evelo Therapeutics, VL28)
Health
$9K
Selecta Biosciences
Health
$84M
Avedro
Health
$100M
Repertoire Immune Medicines
Health
$756M
TransMedics
Health · Unicorn
$3.0B
T2 Biosystems
Health
$23M
Codiak Biosciences
Health
$10M
KSQ Therapeutics
Health
$320M
NuVox
Telecom
$550M
Kaleido Biosciences
Health
Alltrna
Health
$436M
Axcella
Health
AVEO Oncology
Health
$566M
Visterra
Health
$187M
Seres Therapeutics
Health
$97M
Acceleron Pharma
Health · Decacorn
$12B
Quanterix
Health
$102M
Tarveda Therapeutics
Health
$150M
Agios Pharmaceuticals
Health · Unicorn
$1.4B
Sigilon
Health
$29M
Ampersand Biomedicines
Health
$260M
TARIS Biomedical
Health
$100M
Foghorn Therapeutics
Health
$136M
Invaio Sciences
Food
$356M
Concert Pharmaceuticals
Health
$267M
Tetraphase Pharmaceuticals
Health
$43M
Receptos
Health
$120M
BG Medicine
Health
$546K
Seventh Sense Biosystems
Health
$84M
Zalicus
Health
$34M
Black Duck Software
Enterprise Software
$565M
Mascoma
Health
$244M
Renovis
Health
$152M
Helicos BioSciences
Health
Morphotek
Health
$160M
Profound Therapeutics
Health
$300M
Vesalius Therapeutics
Health
$300M
LS9
Energy
$62M
CiBO Technologies
Food
$120M
BIND Therapeutics
Health
Portfolio founders

Where Flagship Pioneering’s portfolio founders come from.

96 founders across the 100 highest-funded portfolio companies — by current location, university attended, and the companies they worked at before founding. Sourced from the founder records the API links to each portfolio company.

LocationCount
  1. United States79
  2. Canada2
  3. United Kingdom2
  4. Australia1
  5. Denmark1
  6. India1
  7. Sweden1
  8. Switzerland1
UniversityCount
  1. Massachusetts Institute of Technology11
  2. Harvard University10
  3. University of California, Berkeley6
  4. Stanford University4
  5. Yale University4
  6. Cornell University3
  7. Harvard Medical School3
  8. University of Cambridge3
  9. Boston University2
  10. ETH Zurich2
Previous companyCount
  1. Massachusetts Institute of Technology11
  2. Pfizer4
  3. Boston Consulting Group3
  4. Genentech3
  5. Harvard Medical School3
  6. MIT-IBM Watson AI Lab3
  7. Biogen2
  8. BU Today2
  9. Bucksurgical2
  10. Flagship Pioneering2
Figures on this page are sourced live from the Dealroom next-gen API, joined with Dealroom’s cap-table dataset (estimated holdings) and the Power Law Investor Ranking. News in “Featured in” is drawn from Dealroom’s own coverage — the stories that name this investor, not only those it is the subject of. Market sentiment is omitted until the API exposes it.