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Orionis Biosciences

Biotech & Life Sciences · Waltham, United States · Founded 2015

Pioneering technological innovation in genome-scale drug discovery and tunable molecular design of novel therapeutic drug modalities MoreLess

Orionis Biosciences is a clinical-stage life sciences company that focuses on the development of innovative medicines for cancer and other diseases. Their approach combines the power of nature with precision drug design to create new treatment modalities and possibilities. The company's primary market is the healthcare sector, specifically targeting patients with advanced solid tumors and other serious diseases.

Orionis' business model revolves around the development and clinical testing of their drug candidates. They are currently in the clinical trial phase for their drug ORB-011, which is being tested as a single agent treatment for patients with advanced solid tumors. The company generates revenue through the successful development, approval, and subsequent sale of their drugs.

The company's pipeline includes targeted cytokine immunotherapies, which are treatments that use the body's immune system to fight diseases, and molecular glue drug modalities. The latter are small molecules that act in a unique way to target and degrade disease-causing proteins, a method that could potentially treat diseases that have been historically difficult to target with drugs.

Orionis also develops A-Kines, a new type of drug that uses common molecular building blocks to create biologics with superior cell target selectivity. This means these drugs can more accurately target and treat specific cells in the body, potentially improving their effectiveness and reducing side effects.

The company is headquartered in Boston, MA, and Ghent, Belgium, and has recently added Tony Fadell, inventor of the iPod and co-inventor of the iPhone, to its board of directors.

Keywords: Life Sciences, Cancer Treatment, Clinical Trials, Drug Development, Cytokine Immunotherapies, Molecular Glue Drug Modalities, A-Kines, Biologics, Advanced Solid Tumors, Healthcare Sector.

Company overview

Orionis Biosciences company information

The essential company record, classifications and operating signals in one place.

Status
Operational
Founded
2015
Headquarters
Waltham, United States
Employees
61
Open positions
None listed
Dealroom signal
86.6
Investment activity
1 companies · latest Feb 2023
Capital deployed
$10M
Preferred round
LATE VC
client focusb2btechnologyDeep Techsub industryPharmaceuticalsub industryBioTechnologybusiness modelManufacturingindustryHealthsectorBiotechnologysectorOncologysectorGenetics and genomicssectorPrecision MedicinesectorSpinoutsectorGenome EngineeringsectorBiotech and PharmasectorAI Drug Discovery

Valuation & funding

Orionis Biosciences funding history

Company financing events and reported valuations.

Deal typeDateAmountValuationInvestorsSource
LATE VCOther financing Oct 2022 $55M $220M Cormorant Asset Management · Novartis
GROWTH EQUITY VCOther financing Jan 2021 $0 Excel Venture Management · CB Health Ventures_1
SERIES BOther financing Mar 2020 $0 Undisclosed
SERIES BOther financing Apr 2018 Undisclosed
SERIES AOther financing Apr 2016 $0 V-Bio Ventures
EARLY VCOther financing Oct 2015 Undisclosed
SPINOUTOther financing Jan 2015 Flanders Institute for Biotechnology · Ghent University
Showing 7 recorded eventsUnlock the complete deal history →

Financials

Revenue, earnings and profit over time

Reported history and available estimates. Estimated years are marked “E”; sparse fields are left blank rather than inferred.

YearRevenueGrowthEBITDAMargin
2026 $10M 0% $1.8M 18%
2025 $10M 0% $1.8M 18%
2024 $10M 0% $1.8M 18%
2023 $10M 0% $1.8M 18%
2022 $10M 0% $1.8M 18%
2021 $10M 0% $1.4M 14.2%
2020 $10M $949K 9.5%
Company filings, research estimates and Dealroom dataOpen the full financial model →

Growth signals

Orionis Biosciences website traffic

Latest recorded traffic for Orionis Biosciences is 3.7K monthly website visits, up 48% over the last three months. Orionis Biosciences's team grew 8.9% over the past year.

Latest monthly visits3.7K 3-month web change+48% 1-year team growth+8.9%
Monthly website visits99 observations · Oct 2017–Jul 2026
Hover or focus a point to see its exact monthly valueCompare with peers →

Comparisons

Orionis Biosciences compared with similar companies

Dealroom’s weighted taxonomy model identifies the closest operating peers. Company identity and context stay open; selected comparison metrics preview what is available in the platform.

Showing 8 of the closest matchesCompare every metric →

Talent graph

Orionis Biosciences's talent

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Team profiled 8 named & role-tagged
Founders Hidden — book a demo/100 quality score
Key operators 3 quality Hidden — book a demo/100
Potential founders Hidden — book a demo likely future founders
Startup mafia Hidden — book a demo alumni-founded startups
Talent movements Hidden — book a demo in · Hidden — book a demo out past 12 months

Source: Dealroom Talent Intelligence.

Investors

7 investors on Orionis Biosciences's cap table

Sourced from Dealroom's funding and investor records. Investor profile links are shown where available.

Series A 1 investor entered at this stage
V-Bio Ventures
Series B+ 4 investors entered at this stage
Excel Venture Management
CB Health Ventures_1
Cormorant Asset Management
Novartis
Other known 2 additional known investors
Flanders Institute for Biotechnology
Ghent University

Global footprint

Where Orionis Biosciences has talent and traffic

Workforce by country
2 countries with
team presence
🇧🇪 Belgium70.8%
🇺🇸 United States29.2%
2 countries shown

In the news

Latest news about Orionis Biosciences

Recent press, funding announcements, and product moves mentioning Orionis Biosciences — open to read from the original sources.

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Market sentiment

What the market is saying about Orionis Biosciences

An AI-synthesized read of the highest-engagement posts about Orionis Biosciences on X over the past 7 days. We rank by likes & retweets, ignore corporate channels, and surface the themes that broke out from real people.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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