Lirio

About Lirio

Lirio is a company specialising in the application of behavioural science and artificial intelligence (AI) to enhance patient engagement and drive better health outcomes. Founded in (or around) 2016-17 and headquartered in Knoxville, Tennessee, the firm’s core offering is a personalisation engine branded as “Precision Nudging®”. This technology analyses individual behaviours, communication patterns and social/clinical context to deliver hyper-personalised messages and interventions—with the aim of overcoming barriers to care and motivating people toward healthier actions. The company was co-founded by Mike West (Executive Chair) and others including Marten den Haring, George d’Andrea and Wade Ponder (among its leadership/early team).

Lirio’s platform integrates behavioural-science principles (such as personas, triggers, habit-formation heuristics) with machine-learning/AI algorithms to create tailored communication for individuals. The system is primarily aimed at healthcare providers, payers and organisations, helping them improve patient adherence to treatment plans, close gaps in care (for example screening, prevention), and encourage ongoing engagement and preventative health measures. Its business model is B2B, partnering with large health systems, payers and provider organisations.

An important part of Lirio’s lineage is Fiveworx: the company traces its roots to Fiveworx—a startup that developed a digital engagement platform for the energy/utilities sector. That platform, built around behavioural-messaging for utility customers, formed a foundation for Lirio’s behavioural-AI stack. Following acquisition (or majority interest) in Fiveworx’s technology by Northshore Management and its integration into Lirio’s business, Lirio expanded the model into healthcare (and other sectors) using the core behavioural engine originally honed in utilities.

Today, Lirio emphasises its role as a personalisation engine for digital health: “We empower you to orchestrate each person’s unique and evolving healthcare journey using hyper-personalised communications that support health outcomes.” The platform is described as supporting one-to-one personalisation (moving past demographic segmentation), sustained engagement (real-time adaptation), and healthier populations (earlier outreach, closing care gaps, lowering total cost of care).