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Ionis Pharmaceuticals

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Carlsbad, United StatesFounded 1989Biotech & Life Sciences
Valuation $6.86B Market cap · 2026
Revenue $920M Latest reported FY

About Ionis Pharmaceuticals

Ionis Pharmaceuticals, accessible via ionispharma.com, is a biotechnology company dedicated to the discovery, development, and delivery of genetic medicines that transform lives. The company focuses on creating treatments that address the root causes of diseases, offering hope and improved futures for patients. Ionis operates in the biopharmaceutical market, specifically targeting genetic disorders and other serious health conditions.

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The company serves a diverse range of clients, including patients, healthcare providers, and pharmaceutical partners. Ionis' business model revolves around leveraging its proprietary technology platform to develop innovative therapies. This platform includes their generation 2.5 chemistry, known as constrained ethyl (cET), which enhances the potency and distribution of their medicines across multiple tissues.

Ionis generates revenue through various streams. Primarily, it earns money by licensing its technology and drug candidates to larger pharmaceutical companies. Additionally, Ionis commercializes its own products through its subsidiary, Akcea Therapeutics, which markets drugs like inotersen and volanesorsen. These products are aimed at treating rare and serious diseases, further solidifying Ionis' position in the market.

The company's commitment to diversity, equity, and inclusion (DEI) is evident in its corporate culture. Ionis fosters an inclusive environment where all employees feel valued and empowered to contribute, leading to better ideas and increased innovation. This inclusive culture is seen as a key driver of the company's success and ability to deliver groundbreaking medicines.

In summary, Ionis Pharmaceuticals is a pioneering biotech firm focused on genetic medicines, serving patients and healthcare providers, and generating revenue through licensing and product commercialization. The company's dedication to innovation and inclusive culture positions it as a leader in the biopharmaceutical industry.

Source: Dealroom company data

At a glance

Status
Listed
Founded
1989
Headquarters
Carlsbad, United States
Listing
IPO 1991
Employees
1,566
Open positions
None listed
Dealroom signal
59.9/100
Industry
Health
Sub-industry
Pharmaceutical, BioTechnology
Sector
Biotech & Life Sciences, Biotechnology, Drug Development
Business model
Manufacturing
Client focus
b2b
Investment activity
4 companies, latest Jan 2021
Capital deployed
$112M
Preferred round
SERIES A

Funding history

6 recorded events

Company financing events and reported valuations.

Deal typeDateAmountValuationInvestorsSource
POST IPO DEBT✓Debt Nov 2025 $0 — Undisclosed ↗
POST IPO CONVERTIBLE✓Other financing Nov 2025 $700M — Undisclosed ↗
Showing the latest 2 of 6 recorded eventsBook a demo for the full funding history →

Financials

Revenue, earnings and profit over time

Revenue, earnings and other financial measures where available. Years marked “E” are estimates.

YearRevenueGrowthEBITDAMarginProfitMarginR&D
2026 $920M -2.6% −$573M -62.3% −$576M -62.7% $916M
2025 $944M +33.8% −$381M -40.4% −$381M -40.4% $916M
2024 $705M -10.5% −$458M -64.9% −$454M -64.4% $902M
2023 $788M +34.2% −$323M -41% $900M
2022 $587M -27.5% −$561M -95.6%
2021 $810M +11.1% −$21M -2.6%
2020 $729M — −$172M -23.6%
Company filings, research estimates and Dealroom dataBook a demo for the full financial model →

Growth signals

Ionis Pharmaceuticals website traffic

Latest recorded traffic for Ionis Pharmaceuticals is 53K monthly website visits, up 39.5% over the last three months. Ionis Pharmaceuticals's team grew 113.6% over the past year.

Latest monthly visits53K 3-month web change+39.5% 1-year team growth+113.6%
Summary metrics are public; monthly history is available with a demoCompare with peers →

Investors

1 investor on the cap table

From Dealroom's funding and investor records, grouped by the round each investor first entered.

Other known investors1 additional known investor

  • Bessemer Venture Partners
Team profiled 81 named & role-tagged
Founders Hidden — book a demo/100 quality score
Key operators 4 quality Hidden — book a demo/100
Potential founders Hidden — book a demo likely future founders
Startup mafia Hidden — book a demo alumni-founded startups
Talent movements Hidden — book a demo in · Hidden — book a demo out past 12 months

Source: Dealroom Talent Intelligence.

Global footprint

Workforce and web traffic by country
Workforce by country
🇺🇸 United States · Carlsbad HQ
Book a demo for the full country breakdown

Market sentiment

Posts on X, past 7 days

An AI-synthesised read of the highest-engagement posts about Ionis Pharmaceuticals on X, ranked by likes and reposts, corporate channels excluded.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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