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Annexon Biosciences

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Biotech company, discovering and developing novel therapeutics for neurodegenerative and autoimmune disorders

San Francisco, United StatesFounded 2011Biotech & Life Sciences
Valuation $549M Market cap · 2026
Total funding $100–500M Disclosed equity funding

About Annexon Biosciences

Annexon Biosciences is a clinical-stage biopharmaceutical company focused on developing innovative therapies for autoimmune and neurodegenerative diseases, including eye-related conditions. The company operates in the biopharmaceutical market, targeting diseases such as Alzheimer's, Huntington's, and glaucoma.

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Annexon's unique approach centers on the classical complement pathway, a part of the immune system that, when improperly activated, can lead to tissue damage. Their primary focus is on inhibiting C1q, the molecule that initiates this pathway. By blocking C1q, Annexon aims to prevent the cascade of events that cause disease progression, effectively "stopping the start" of these conditions.

The company's business model involves extensive research and development (R&D) to create these novel therapies. They conduct clinical trials to test the safety and effectiveness of their treatments. Once a therapy proves successful, Annexon can either bring it to market themselves or partner with larger pharmaceutical companies to distribute it. This model allows them to generate revenue through product sales, licensing agreements, and milestone payments from partners.

Annexon's clients primarily include patients suffering from autoimmune and neurodegenerative diseases, healthcare providers, and larger pharmaceutical companies looking for innovative treatments to add to their portfolios. The company recently secured $100 million in financing to advance its pipeline of therapies, highlighting strong investor confidence in their approach and potential.

In summary, Annexon Biosciences is at the forefront of developing first-in-class therapies targeting the classical complement pathway to treat a range of serious diseases. Their innovative approach and strong financial backing position them well in the competitive biopharmaceutical market.

Source: Dealroom company data

At a glance

Status
Operational
Founded
2011
Headquarters
San Francisco, United States
Listing
IPO 2020
Employees
116
Open positions
4
Dealroom signal
34.4/100
Industry
Health
Sub-industry
Pharmaceutical, BioTechnology
Sector
Biotech & Life Sciences, Biotechnology, Ophthalmology, Neurology, Autoimmune, Eye Diseases, Degenerative Diseases, Health Diagnostics, Spinout, Biotech and Pharma
Business model
Manufacturing
Client focus
b2b

Funding history

10 recorded events

Company financing events and reported valuations.

Deal typeDateAmountValuationInvestorsSource
POST IPO EQUITYOther financing Nov 2025 $75M — Undisclosed ↗
POST IPO EQUITYOther financing Jun 2024 $125M — Undisclosed ↗
Showing the latest 2 of 10 recorded eventsBook a demo for the full funding history →

Financials

Revenue, earnings and profit over time

Revenue, earnings and other financial measures where available. Years marked “E” are estimates.

YearRevenueGrowthEBITDAMargin
2026 $0 — −$214M —
2025 $0 — −$214M —
2024 $0 — −$151M —
2023 $0 — −$142M —
2022 $0 — −$146M —
2021 $0 — −$131M —
2020 $0 — −$63M —
Company filings, research estimates and Dealroom dataBook a demo for the full financial model →

Growth signals

Annexon Biosciences website traffic

Latest recorded traffic for Annexon Biosciences is 4.9K monthly website visits, down 41.7% over the last three months. Annexon Biosciences's team declined 2.5% over the past year.

Latest monthly visits4.9K 3-month web change-41.7% 1-year team growth-2.5%
Summary metrics are public; monthly history is available with a demoCompare with peers →

Similar companies

Closest operating peers by Dealroom taxonomy

Company identity and context are open; selected comparison metrics preview what is available on the platform.

Showing 8 of the closest matchesCompare every metric →

Investments and acquisitions

Capital deployed

Recent portfolio relationships for companies that also act as investors or acquirers.

Investors

18 investors on the cap table

From Dealroom's funding and investor records, grouped by the round each investor first entered.

Series A4 investors entered at this stage

  • Novartis Venture Fund
  • Clarus Ventures
  • NEA
  • Correlation Ventures

Series B and later13 investors entered at this stage

Other known investors1 additional known investor

  • Stanford University
Team profiled 14 named & role-tagged
Founders Hidden — book a demo/100 quality score
Key operators 2 quality Hidden — book a demo/100
Potential founders Hidden — book a demo likely future founders
Startup mafia Hidden — book a demo alumni-founded startups
Talent movements Hidden — book a demo in · Hidden — book a demo out past 12 months

Source: Dealroom Talent Intelligence.

Global footprint

Workforce and web traffic by country
Workforce by country
3 countries with
team presence
🇺🇸 United States97.9%
🇵🇭 Philippines1%
🇫🇷 France1%
3 countries shown

Market sentiment

Posts on X, past 7 days

An AI-synthesised read of the highest-engagement posts about Annexon Biosciences on X, ranked by likes and reposts, corporate channels excluded.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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