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Affinia Therapeutics
A proprietary rational design platform that enables to methodically engineer the next generation of AAV vectors and gene therapies
About Affinia Therapeutics
Affinia Therapeutics is a pioneering biotechnology startup that is revolutionizing the field of gene therapy. The company's primary focus is on developing innovative treatments for rare and prevalent diseases, particularly those affecting the nervous system, neuro-oncology, muscle, and lung.
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The company operates in the rapidly expanding market of gene therapy, which involves modifying or introducing genes into a patient's cells to treat or prevent disease. Affinia Therapeutics is at the forefront of this field, using its proprietary Affinia Rationally-designed Therapies (ART) platform to design the gene therapies of the future. This platform allows the company to understand how the structure of a gene impacts its function, enabling them to create more effective treatments.
Affinia Therapeutics' business model is centered around the development and commercialization of these gene therapies. The company creates libraries of adeno-associated viruses (AAVs), which are commonly used in gene therapy due to their ability to deliver genes to cells. By developing new AAVs, Affinia Therapeutics is able to expand the possibilities of gene therapy and create transformative medicines for people in need.
The company's clients are primarily patients suffering from devastating diseases, for whom traditional treatments have been ineffective. By providing these patients with innovative gene therapies, Affinia Therapeutics is able to make a lasting positive impact on their lives.
In terms of revenue, Affinia Therapeutics likely makes money by selling its gene therapies to healthcare providers or directly to patients. As the company continues to develop and commercialize new therapies, its revenue potential in the growing gene therapy market is significant.
At a glance
- Status
- Operational
- Founded
- 2019
- Headquarters
- Waltham, United States
- Employees
- 33
- Open positions
- 1
- Dealroom signal
- 62.0/100
- Industry
- Health
- Sub-industry
- BioTechnology
- Sector
- Biotech & Life Sciences, Biotechnology, Spinout, Biotech and Pharma, DT and LS, science-based
- Business model
- Manufacturing
- Client focus
- b2b
Latest news
Press, funding announcements and product moves mentioning Affinia Therapeutics.
Funding history
Company financing events and reported valuations.
| Deal type | Date | Amount | Valuation | Investors | Source |
|---|---|---|---|---|---|
| SERIES COther financing | Oct 2025 | $40M | $550M | Atlas Venture · GV · Alexandria Venture Investments · Avidity Partners | ↗ |
| SERIES BOther financing | May 2021 | $110M | $440M | F-Prime · RA Capital Management · Perceptive Advisors · Woodline Partners | — |
Growth signals
Latest recorded traffic for Affinia Therapeutics is 3.7K monthly website visits, down 2.6% over the last three months. Affinia Therapeutics's team declined 34% over the past year.
Open positions
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Investors
From Dealroom's funding and investor records, grouped by the round each investor first entered.
Series A14 investors entered at this stage
NEA
F-Prime
Atlas Venture
Lonza
Alexandria Venture Investments
Farallon Capital Management
EcoR1 Capital
RA Capital Management
Perceptive Advisors
Woodline Partners
Casdin Capital
Octagon Capital Partners
Avidity Partners
TCGX
Series B and later3 investors entered at this stage
GV
Eli Lilly
Mass General Brigham Ventures
Other known investors3 additional known investors
Harvard Medical School
Institute of Molecular and Clinical Ophthalmology Basel (IOB)
Massachusetts Eye and Ear
Source: Dealroom Talent Intelligence.
Global footprint
team presence
Market sentiment
An AI-synthesised read of the highest-engagement posts about Affinia Therapeutics on X, ranked by likes and reposts, corporate channels excluded.
Reading the room on X — pulling top posts and synthesizing themes…
Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour
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