Shape Therapeutics

About Shape Therapeutics

ShapeTX is a cutting-edge biotechnology startup that operates in the field of programmable RNA medicine. The company uses artificial intelligence (AI) to analyze large datasets and make intelligent decisions about the development of new medicines. The company's primary focus is on RNA, a molecule that plays a crucial role in the coding, decoding, regulation, and expression of genes. ShapeTX believes that RNA has nearly unlimited therapeutic potential and can be used to solve the underlying cause of many diseases.

The company's business model revolves around the use of AI and RNA technology to discover and design new medicines. These medicines are not only effective and safe but also easy to manufacture. ShapeTX uses AI to design novel RNAs that can reprogram cells to prevent or fight disease. This includes everything from correcting mutations to fine-tuning gene expression to modulating protein-protein interaction.

ShapeTX's platform screens large genomic datasets to find new treatment possibilities for even the hardest-to-treat diseases. One of their key technologies, RNAfix, uses a naturally occurring enzyme found in all human cells to correct the body’s instructions for making proteins by recoding RNA, without permanent changes to DNA. This can be used to correct mutations or purposefully create them to treat a wide range of genetic disorders.

The company also uses smart-sensing vector designs to tailor gene expression for each gene and target cell type, enabling new treatment possibilities beyond first-generation gene replacement approaches. The ShapeTX AI-driven platform rationally engineers billions of viral capsids to find the one that can precisely deliver the RNA medicine to specific tissues or cells.