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Second Genome

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Offers a pipeline of microbiome modulators that impact infection, immunity and metabolic diseases

South San Francisco, United StatesFounded 2009Biotech & Life Sciences
Valuation $100–250M Last recorded · 2019
Headcount <100 Current team size
Total funding $50–100M Disclosed equity funding
Unlock exact values This page shows ranges. Dealroom has the exact numbers for Second Genome and the history behind them.

About Second Genome

Second Genome is a biotechnology startup that operates in the pharmaceutical industry, specializing in the discovery and development of precision therapies. The company uses a unique approach that extends beyond traditional human biology to identify potential drug targets and therapies. This approach is supported by a suite of proprietary tools and capabilities that allow for mass data integration, machine learning, and strain-level identification, which are all unique to Second Genome.

The company's primary focus is on inflammatory bowel disorders and solid tumors. It has two advanced programs in IND-enabling studies and eight additional programs in early discovery. Its lead development candidate, SG-5-00455, has shown potential to become the first in its class to directly target mucosal healing in patients with inflammatory bowel disease (IBD). Another promising candidate, SG-3-06686, has demonstrated potential as a first-in-class CXCR3 immune activator that can inhibit tumor growth.

Second Genome's business model revolves around the discovery of novel therapeutics and biomarkers, which are then patented (IP filed) for potential commercialization. The company also collaborates with other businesses, as evidenced by its multi-year collaboration with Bayer, where it discovered diverse and novel proteins for potential development of next-generation insect-control products.

In terms of revenue, Second Genome likely earns money through the licensing of its proprietary technologies, partnerships with other pharmaceutical companies, and potentially, the sale of its developed drugs once they receive regulatory approval.

Source: Dealroom company data

At a glance

Status
Operational
Founded
2009
Headquarters
South San Francisco, United States
Employees
4
Open positions
None listed
Dealroom signal
62.5/100
Industry
Health
Sub-industry
BioTechnology
Sector
Biotech & Life Sciences, Biotechnology, DNA, Genetics and genomics, Microbiology, Nutrition, Spinout, Biotech and Pharma, DT and LS, science-based
Client focus
b2b

Funding history

7 recorded events

Company financing events and reported valuations.

Deal typeDateAmountValuationInvestorsSource
SERIES BOther financing Mar 2019 $25M $100M SR One · Morgenthaler Ventures · Roche Venture Fund · Advanced Technology Ventures —
GRANTOther financing Oct 2017 $0 — Undisclosed —
Showing the latest 2 of 7 recorded eventsBook a demo for the full funding history →

Growth signals

Second Genome website traffic

Latest recorded traffic for Second Genome is 200 monthly website visits, down 80% over the last three months. Second Genome's team declined 33.3% over the past year.

Latest monthly visits200 3-month web change-80% 1-year team growth-33.3%
Summary metrics are public; monthly history is available with a demoCompare with peers →

Similar companies

Closest operating peers by Dealroom taxonomy

Company identity and context are open; selected comparison metrics preview what is available on the platform.

Showing 8 of the closest matchesCompare every metric →

Investments and acquisitions

Capital deployed

Recent portfolio relationships for companies that also act as investors or acquirers.

Investors

11 investors on the cap table

From Dealroom's funding and investor records, grouped by the round each investor first entered.

Series A10 investors entered at this stage

  • Morgenthaler Ventures
  • Advanced Technology Ventures
  • SR One
  • Matthew Winkler
  • Adveq
  • Digitalis Ventures
  • Mayo Clinic
  • Roche Venture Fund
  • Seraph Group
  • MBL Venture Capital

Other known investors1 additional known investor

  • Berkeley Lab
Team profiled 11 named & role-tagged
Founders Hidden — book a demo/100 quality score
Key operators 2 quality Hidden — book a demo/100
Potential founders Hidden — book a demo likely future founders
Startup mafia Hidden — book a demo alumni-founded startups
Talent movements Hidden — book a demo in · Hidden — book a demo out past 12 months

Source: Dealroom Talent Intelligence.

Global footprint

Workforce and web traffic by country
Workforce by country
1 countries with
team presence
🇺🇸 United States100%
1 country shown

Market sentiment

Posts on X, past 7 days

An AI-synthesised read of the highest-engagement posts about Second Genome on X, ranked by likes and reposts, corporate channels excluded.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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