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Profluent

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Generative AI platform designing functional proteins for therapeutics

Emeryville, United StatesFounded 2022Biotech & Life Sciences
Valuation $500M–1B Last recorded · 2025
Headcount <100 Current team size
Total funding $100–500M Disclosed equity funding
Unlock exact values This page shows ranges. Dealroom has the exact numbers for Profluent and the history behind them.

About Profluent

Profluent.bio is a cutting-edge startup that operates at the intersection of artificial intelligence (AI) and biology. The company specializes in creating custom proteins designed for breakthrough medicines, aiming to revolutionize genetic medicine. Profluent.bio serves clients in the pharmaceutical and biotechnology sectors, particularly those focused on developing treatments for genetic diseases.

The market Profluent.bio operates in is the rapidly growing field of gene editing and synthetic biology. This market is driven by the increasing demand for innovative therapies that can address previously untreatable genetic conditions. The company's unique approach leverages AI to optimize protein design, making it more efficient and cost-effective for their partners to achieve commercial success.

Profluent.bio's business model is based on partnerships with pharmaceutical and biotech companies. They provide these partners with bespoke protein solutions that are tailored to specific therapeutic needs. By using AI to decode the "language of life," Profluent.bio can create proteins that go beyond the capabilities of natural or existing patented proteins. This allows their partners to develop more effective and precise treatments.

The company generates revenue through these partnerships, likely involving a combination of upfront fees, milestone payments, and royalties on the successful commercialization of the therapies developed using their proteins.

In summary, Profluent.bio is a pioneering company that uses AI to create custom proteins for genetic medicine, serving pharmaceutical and biotech clients. They operate in the gene editing and synthetic biology market, with a business model focused on partnerships and revenue from collaborative projects.

Source: Dealroom company data

At a glance

Status
Operational
Founded
2022
Headquarters
Emeryville, United States
Employees
69
Open positions
17
Dealroom signal
94.7/100
Industry
Health
Sub-industry
BioTechnology
Sector
Biotech & Life Sciences, Biotechnology, Drug Development, Core AI, Precision Medicine, Synthetic Biology, Crispr, Novel AI
Technology
Artificial Intelligence, Deep Tech, Machine Learning
Business model
Manufacturing
Client focus
b2b

Funding history

3 recorded events

Company financing events and reported valuations.

Deal typeDateAmountValuationInvestorsSource
LATE VCOther financing Nov 2025 $106M $424M Spark Capital · Air Street Capital · Convergent Ventures · Altimeter Capital ↗
EARLY VCOther financing Mar 2024 $35M $140M Insight Partners · Jeff Dean · Air Street Capital · Spark Capital ↗
Showing the latest 2 of 3 recorded eventsBook a demo for the full funding history →

Growth signals

Profluent website traffic

Latest recorded traffic for Profluent is 8.2K monthly website visits, down 5.7% over the last three months. Profluent's team grew 46.8% over the past year.

Latest monthly visits8.2K 3-month web change-5.7% 1-year team growth+46.8%
Summary metrics are public; monthly history is available with a demoCompare with peers →

Similar companies

Closest operating peers by Dealroom taxonomy

Company identity and context are open; selected comparison metrics preview what is available on the platform.

Showing 8 of the closest matchesCompare every metric →

Investments and acquisitions

Capital deployed

Recent portfolio relationships for companies that also act as investors or acquirers.

Investors

8 investors on the cap table

From Dealroom's funding and investor records, grouped by the round each investor first entered.

Series A4 investors entered at this stage

Series B and later4 investors entered at this stage

Team profiled 12 named & role-tagged
Founders Hidden — book a demo/100 quality score
Key operators 2 quality Hidden — book a demo/100
Potential founders Hidden — book a demo likely future founders
Startup mafia Hidden — book a demo alumni-founded startups
Talent movements Hidden — book a demo in · Hidden — book a demo out past 12 months

Source: Dealroom Talent Intelligence.

Global footprint

Workforce and web traffic by country
Workforce by country
2 countries with
team presence
🇺🇸 United States98.1%
🇫🇷 France1.9%
2 countries shown

Market sentiment

Posts on X, past 7 days

An AI-synthesised read of the highest-engagement posts about Profluent on X, ranked by likes and reposts, corporate channels excluded.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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