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Profluent
Generative AI platform designing functional proteins for therapeutics
About Profluent
Profluent.bio is a cutting-edge startup that operates at the intersection of artificial intelligence (AI) and biology. The company specializes in creating custom proteins designed for breakthrough medicines, aiming to revolutionize genetic medicine. Profluent.bio serves clients in the pharmaceutical and biotechnology sectors, particularly those focused on developing treatments for genetic diseases.
The market Profluent.bio operates in is the rapidly growing field of gene editing and synthetic biology. This market is driven by the increasing demand for innovative therapies that can address previously untreatable genetic conditions. The company's unique approach leverages AI to optimize protein design, making it more efficient and cost-effective for their partners to achieve commercial success.
Profluent.bio's business model is based on partnerships with pharmaceutical and biotech companies. They provide these partners with bespoke protein solutions that are tailored to specific therapeutic needs. By using AI to decode the "language of life," Profluent.bio can create proteins that go beyond the capabilities of natural or existing patented proteins. This allows their partners to develop more effective and precise treatments.
The company generates revenue through these partnerships, likely involving a combination of upfront fees, milestone payments, and royalties on the successful commercialization of the therapies developed using their proteins.
In summary, Profluent.bio is a pioneering company that uses AI to create custom proteins for genetic medicine, serving pharmaceutical and biotech clients. They operate in the gene editing and synthetic biology market, with a business model focused on partnerships and revenue from collaborative projects.
Source: Dealroom company dataAt a glance
- Status
- Operational
- Founded
- 2022
- Headquarters
- Emeryville, United States
- Employees
- 69
- Open positions
- 17
- Dealroom signal
- 94.7/100
- Industry
- Health
- Sub-industry
- BioTechnology
- Sector
- Biotech & Life Sciences, Biotechnology, Drug Development, Core AI, Precision Medicine, Synthetic Biology, Crispr, Novel AI
- Technology
- Artificial Intelligence, Deep Tech, Machine Learning
- Business model
- Manufacturing
- Client focus
- b2b
Knowledge graph
More headlines
Funding history
Company financing events and reported valuations.
| Deal type | Date | Amount | Valuation | Investors | Source |
|---|---|---|---|---|---|
| LATE VCOther financing | Nov 2025 | $106M | $424M | Spark Capital · Air Street Capital · Convergent Ventures · Altimeter Capital | ↗ |
| EARLY VCOther financing | Mar 2024 | $35M | $140M | Insight Partners · Jeff Dean · Air Street Capital · Spark Capital | ↗ |
Growth signals
Latest recorded traffic for Profluent is 8.2K monthly website visits, down 5.7% over the last three months. Profluent's team grew 46.8% over the past year.
Open positions
Similar companies
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Investments and acquisitions
Recent portfolio relationships for companies that also act as investors or acquirers.
Investors
From Dealroom's funding and investor records, grouped by the round each investor first entered.
Series A4 investors entered at this stage
Spark Capital
Insight Partners
Jeff Dean
Air Street Capital
Series B and later4 investors entered at this stage
Altimeter Capital
Bezos Expeditions
Convergent Ventures
AIX Ventures
Source: Dealroom Talent Intelligence.
Global footprint
team presence
Market sentiment
An AI-synthesised read of the highest-engagement posts about Profluent on X, ranked by likes and reposts, corporate channels excluded.
Reading the room on X — pulling top posts and synthesizing themes…
Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour
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