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Orna Therapeutics

Biotech & Life Sciences · Cambridge, United States · Founded 2019

Ornatx is a pioneering biotech startup that is revolutionizing the field of RNA therapeutics. The company's innovative approach involves shifting from linear to circular RNA, a move that opens up a plethora of possibilities in disease treatment. Ornatx's engineered circular RNA (oRNA™) offers significant advantages over traditional linear forms, making it a promising tool in the fight against various diseases. The company's technology has wide-ranging applications, spanning multiple disease areas such as cancer, regenerative medicine, protein replacement, infectious diseases, and autoimmunity. Its flagship program is an in situ CAR therapy that uses oRNA™ molecules and proprietary lipid nanoparticles (LNPs) to deliver chimeric antigen receptors (CARs) directly to a patient's immune cells within the body. This innovative therapy could represent a significant advancement over traditional cell engineering therapies. Ornatx operates in the biotech market, serving clients in the healthcare and medical research sectors. The company's business model revolves around the development and commercialization of its groundbreaking oRNA™ therapeutics. It generates revenue through partnerships with healthcare providers and research institutions, as well as through the potential sale of its therapies once they receive regulatory approval. The company is led by a team of seasoned scientists, molecular engineers, and industry veterans, including Tom, a veteran entrepreneur with over 20 years of experience in turning scientific visions into successful businesses. Keywords: RNA Therapeutics, Circular RNA, Disease Treatment, Cancer, Regenerative Medicine, Protein Replacement, Infectious Diseases, Autoimmunity, In Situ CAR Therapy, Biotech Startup.

Valuation $1–2.5B
Revenue $100–500M
Headcount 100–500
Total funding $100–500M
Unlock exact values This page shows ranges. Dealroom has the exact numbers for Orna Therapeutics and the history behind them.

Investors

14 investors on Orna Therapeutics's cap table

Sourced from Dealroom's funding history.

Series A 11 investors entered at this stage
F2 Ventures
Taiho Ventures
MPM BioImpact
Bristol-Myers Squibb
Taiho Pharma
Kite Pharma
Astellas Venture
Novartis Institutes
PAG
Merck & Co.
BioImpact Capital
Series B+ 3 investors entered at this stage
Massachusetts Institute of Technology
BioImpact Capital
Merck & Co.

Global footprint

Where Orna Therapeutics has talent and traffic

Workforce by country
4 countries with
team presence
🇺🇸 United States97.8%
🇪🇸 Spain0.7%
🇪🇹 Ethiopia0.7%
🇦🇺 Australia0.7%
4 countries shown
Web traffic by country
10K monthly visits
across markets
🇺🇸 United States54%
🏳️ Korea19%
🏳️ Republic of13%
🇬🇧 United Kingdom8%
🇮🇳 India5%
Top 5 markets shown

Talent graph

The shape of Orna Therapeutics's talent

Dealroom maps Orna Therapeutics's team person by person — pinpointing the standout operators and scoring them across the six dimensions investors underwrite. The counts and shape below are a public preview; the named individuals and exact scores live in the platform.

7 standout operatorsDealroom-flagged across the org
1 AI specialistincl. 1 core researchers
118 employees mappedperson by person
DimensionScore
AI Talentlive Score hidden — book a demo
Engineering Score hidden — book a demo
Product Score hidden — book a demo
Go-to-market Score hidden — book a demo
Leadership Score hidden — book a demo
Research Score hidden — book a demo
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Source: Dealroom Talent Intelligence. Public profiles show counts and the team's shape only — request a demo for the named individuals, per-person seniority and tenure, and team benchmarks vs peers.

Patent intelligence

$5M patent portfolio · 17 active families

Estimated portfolio value
$5M
0.22% of valuation · 17.8× larger than top peer Kelonia Therapeutics ($291k)
17 active patent families
Where Orna Therapeutics innovates Antigen receptorBiochemistryCell biologyCircular RNAIn vivo

Where Orna Therapeutics concentrates vs peers

Each axis is a top-10 topic across Orna Therapeutics and its closest peers. #1 = 100, #10 = 10, absent = 0.

Compare against

Source: Dealroom Patent Intelligence · Patsnap. Request a demo for the full per-sub-category breakdown, individual records, and quality-score history.

Market sentiment

What the market is saying about Orna Therapeutics

An AI-synthesized read of the highest-engagement posts about Orna Therapeutics on X over the past 7 days. We rank by likes & retweets, ignore corporate channels, and surface the themes that broke out from real people.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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