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A2biotherapeutics

Biotech & Life Sciences · Agoura Hills, United States · Founded 2018

A radical new way to treat solid tumors. Powerful & precise T cell therapy that attacks solid tumors while sparing normal cells MoreLess

A2 Bio is a groundbreaking biotechnology startup that is revolutionizing the treatment of solid tumors through its proprietary Tmod™ platform. The company's primary focus is on developing innovative treatments for solid tumors, a type of cancer that begins in the solid organs such as the lungs, colon, or breast.

The Tmod™ platform is a powerful and precise T cell therapy that targets and attacks tumor cells while sparing normal cells. This is achieved by integrating multiple signals and exploiting specific gene losses that are only found in tumor cells, thereby overcoming the limitations of conventional single-target therapies.

A2 Bio's business model is centered on the development and commercialization of its Tmod™ platform. The company generates revenue through the clinical trials and eventual sale of its innovative cell therapies. A2 Bio's market is primarily patients suffering from solid tumors, including colorectal, pancreatic, and non-small cell lung cancers.

The company has a first-mover advantage in exploiting the loss of genetic material in cancer cells, a unique approach that sets it apart in the competitive biotech industry. A2 Bio is led by a seasoned management team with over 90 years of combined experience in cell therapy and biotechnology.

Recently, A2 Bio has made significant strides in its research and development efforts. In 2023, the company announced the first patient dosed in a Phase 1 clinical trial of A2B530, a novel cell therapy for the treatment of colorectal, pancreatic, and non-small cell lung cancers.

Keywords: Biotechnology, Solid Tumors, T Cell Therapy, Tmod™ Platform, Cancer Treatment, Cell Therapy, Genetic Material, Clinical Trials, Colorectal Cancer, Pancreatic Cancer, Non-small Cell Lung Cancer.

Company overview

A2biotherapeutics company information

The essential company record, classifications and operating signals in one place.

Status
Operational
Founded
2018
Headquarters
Agoura Hills, United States
Employees
118
Open positions
1
Dealroom signal
66.6
client focusb2bsub industryPharmaceuticalsub industryBioTechnologybusiness modelManufacturingindustryHealthsectorBiotechnologysectorOncologysectorBiotech and PharmasectorDT and LSsectorscience-based

Valuation & funding

A2biotherapeutics funding history

Company financing events and reported valuations.

Deal typeDateAmountValuationInvestorsSource
SERIES COther financing May 2025 $80M $320M The Column Group · Samsara BioCapital
SERIES COther financing Jan 2025 $80M $320M The Column Group · Samsara BioCapital
SERIES BOther financing Dec 2022 $62M $358M Undisclosed
SERIES BOther financing Oct 2020 $72M $286M Nextech Invest
SERIES AOther financing Nov 2019 $57M $228M Nextech Invest
SEEDOther financing Jan 2019 Vida Ventures
Showing 6 recorded eventsUnlock the complete deal history →

Growth signals

A2biotherapeutics website traffic

Latest recorded traffic for A2biotherapeutics is 5.4K monthly website visits, down 20.6% over the last three months. A2biotherapeutics's team declined 4.8% over the past year.

Latest monthly visits5.4K 3-month web change-20.6% 1-year team growth-4.8%
Monthly website visits68 observations · Nov 2020–Jul 2026
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Comparisons

A2biotherapeutics compared with similar companies

Dealroom’s weighted taxonomy model identifies the closest operating peers. Company identity and context stay open; selected comparison metrics preview what is available in the platform.

Showing 8 of the closest matchesCompare every metric →

Talent graph

A2biotherapeutics's talent

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Team profiled 9 named & role-tagged
Founders Hidden — book a demo/100 quality score
Key operators 2 quality Hidden — book a demo/100
Potential founders Hidden — book a demo likely future founders
Startup mafia Hidden — book a demo alumni-founded startups
Talent movements Hidden — book a demo in · Hidden — book a demo out past 12 months

Source: Dealroom Talent Intelligence.

Investors

4 investors on A2biotherapeutics's cap table

Sourced from Dealroom's funding and investor records.

Seed 1 investor entered at this stage
Vida Ventures
Series A 1 investor entered at this stage
Nextech Invest
Series B+ 2 investors entered at this stage
The Column Group
Samsara BioCapital

Global footprint

Where A2biotherapeutics has talent and traffic

Workforce by country
3 countries with
team presence
🇺🇸 United States97.9%
🇭🇰 Hong Kong1%
🇨🇦 Canada1%
3 countries shown

In the news

Latest news about A2biotherapeutics

Recent press, funding announcements, and product moves mentioning A2biotherapeutics — open to read from the original sources.

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Market sentiment

What the market is saying about A2biotherapeutics

An AI-synthesized read of the highest-engagement posts about A2biotherapeutics on X over the past 7 days. We rank by likes & retweets, ignore corporate channels, and surface the themes that broke out from real people.

Reading the room on X — pulling top posts and synthesizing themes…

Source: X recent search ranked by engagement (likes + retweets) · Synthesis by Claude · Cached for 1 hour

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